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The Human Emulation System A complete Organ-on-a-Chip solution. The Human Emulation System combines instruments, consumables, and software, enabling unprecedented insights into human biology across a variety of organs.
Emulate
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A complete Organ-on-a-Chip solution.
The Human Emulation System combines instruments, consumables, and software, enabling unprecedented insights into human biology across a variety of organs.

Alternatives to Animal Testing
Colon Intestine-Chip Investigate mechanisms of colon inflammation and barrier disruption and evaluate the efficacy of anti-inflammatory drug candidates in an organoid-derived model.
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Investigate mechanisms of colon inflammation and barrier disruption and evaluate the efficacy of anti-inflammatory drug candidates in an organoid-derived model.

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Lung-Chip Study lung physiology, disease, and the effect of drug candidates. (Under Development)
Emulate
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Study lung physiology, disease, and the effect of drug candidates.
(Under Development)

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Brain-Chip Study human physiology, disease, and drug effect in a comprehensive model of the neurovascular unit. (Under Development)
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Study human physiology, disease, and drug effect in a comprehensive model of the neurovascular unit.
(Under Development)

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Kidney-Chip Evaluate drug candidate toxicity at clinically relevant concentrations in a co-culture human kidney model
Emulate
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Evaluate drug candidate toxicity at clinically relevant concentrations in a co-culture human kidney model

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Duodenum Intestine-Chip Study drug absorption and drug-drug interactions in a primary organoid-based model of the human small intestine
Emulate
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Study drug absorption and drug-drug interactions in a primary organoid-based model of the human small intestine

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Liver-Chip Investigate mechanisms of toxicity for preclinical drug candidates to help decrease clinical trial safety failures. A new gold standard for assessing human-relevant liver toxicity
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Investigate mechanisms of toxicity for preclinical drug candidates to help decrease clinical trial safety failures.
A new gold standard for assessing human-relevant liver toxicity

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Barrier-on-Chip System Our barrier-on-chip allows the modeling of a wide range of tissue barriers. The soft cell culture substrate facilitates cell attachment and the establishment of tight mono- and co-cultures. It is perfectly suitable for modeling various tissue barriers such as lung, gut, skin, brain, kidney, etc. using cell lines, induced pluripotent stem, or primary cells.
AlveoliX
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Our barrier-on-chip allows the modeling of a wide range of tissue barriers. The soft cell culture substrate facilitates cell attachment and the establishment of tight mono- and co-cultures.
It is perfectly suitable for modeling various tissue barriers such as lung, gut, skin, brain, kidney, etc. using cell lines, induced pluripotent stem, or primary cells.

Alternatives to Animal Testing
EpiOcular™ EpiOcular’s exceptional reproducibility provides scientists with quantifiable assessments of irritation. Its correlation to in vivo sensitivity makes it an ideal in vitro alternative to in vivo testing for toxicological evaluation of raw materials and final formulations.
MatTek
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EpiOcular’s exceptional reproducibility provides scientists with quantifiable assessments of irritation. Its correlation to in vivo sensitivity makes it an ideal in vitro alternative to in vivo testing for toxicological evaluation of raw materials and final formulations.

Alternatives to Animal Testing
EpiIntestinal™ A human 3D in vitro small intestinal tissue model with epithelial polarity to evaluate toxicity, metabolism, drug absorption and compound efficacy. MatTek’s novel innovation to help redefine gastrointestinal preclinical testing.
MatTek
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A human 3D in vitro small intestinal tissue model with epithelial polarity to evaluate toxicity, metabolism, drug absorption and compound efficacy. MatTek’s novel innovation to help redefine gastrointestinal preclinical testing.

Alternatives to Animal Testing
EpiOral™ & EpiGingival™ Personal care and pharmaceutical companies rely on MatTek’s oral mucosal models to evaluate their raw materials and final product formulations.
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Personal care and pharmaceutical companies rely on MatTek’s oral mucosal models to evaluate their raw materials and final product formulations.

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EpiDermFT™ MatTek’s advanced 3D full thickness model of Human Skin takes preclinical testing to the next level by providing a physiological means to evaluate early molecular markers of efficacy.
MatTek
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MatTek’s advanced 3D full thickness model of Human Skin takes preclinical testing to the next level by providing a physiological means to evaluate early molecular markers of efficacy.

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EpiDerm™ MatTek’s patented EpiDerm system is a leading in vitro testing technology for dermal toxicologists and formulation scientists. With multiple ECVAM validations and OECD accepted test guidelines, EpiDerm is a proven in vitro model system for chemical, pharmaceutical and skin care product testing.
MatTek
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MatTek’s patented EpiDerm system is a leading in vitro testing technology for dermal toxicologists and formulation scientists. With multiple ECVAM validations and OECD accepted test guidelines, EpiDerm is a proven in vitro model system for chemical, pharmaceutical and skin care product testing.

Alternatives to Animal Testing
EpiCorneal™ The EpiCorneal 3D human tissue model provides a highly predictive non-animal alternative to assess ophthalmic drug delivery, wound healing and tissue regeneration, disease modeling (e.g. dry eye) and corneal infection.
MatTek
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The EpiCorneal 3D human tissue model provides a highly predictive non-animal alternative to assess ophthalmic drug delivery, wound healing and tissue regeneration, disease modeling (e.g. dry eye) and corneal infection.

Alternatives to Animal Testing
EpiAlveolar™ EpiAlveolar is a 3D co-culture model of the air-blood barrier. Produced from primary human alveolar epithelial cells, pulmonary endothelial cells and fibroblasts, EpiAlveolar is a in vitro model system developed to mimic human-relevant biological responses. Ready-to-Use EpiAlveolar kits are delivered to our customers in a standard 12-well transwell format and include 24 tissue inserts, maintenance medium, and protocols.
MatTek
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EpiAlveolar is a 3D co-culture model of the air-blood barrier. Produced from primary human alveolar epithelial cells, pulmonary endothelial cells and fibroblasts, EpiAlveolar is a in vitro model system developed to mimic human-relevant biological responses. Ready-to-Use EpiAlveolar kits are delivered to our customers in a standard 12-well transwell format and include 24 tissue inserts, maintenance medium, and protocols.

Alternatives to Animal Testing
EpiAirway™ MatTek’s 3D tissue models of the human airway are advancing in vitro respiratory research worldwide. Allowing for physiological exposures to pathogens, chemicals or therapeutics, EpiAirway’s human-relevant biological responses are changing the way scientists research respiratory diseases and drug development. Let EpiAirway advance your science.
MatTek
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MatTek’s 3D tissue models of the human airway are advancing in vitro respiratory research worldwide. Allowing for physiological exposures to pathogens, chemicals or therapeutics, EpiAirway’s human-relevant biological responses are changing the way scientists research respiratory diseases and drug development. Let EpiAirway advance your science.

Alternatives to Animal Testing
SkinEthicTM HVE / Human Vaginal Epithelium The SkinEthicTM HVE model is composed of A431 cells (derived from a vulval epidermoid carcinoma) cultivated on an inert polycarbonate filter at the air liquid interface in a chemically defined medium. This model is histologically similar to the in vivo vaginal mucosa.
EPISKIN
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The SkinEthicTM HVE model is composed of A431 cells (derived from a vulval epidermoid carcinoma) cultivated on an inert polycarbonate filter at the air liquid interface in a chemically defined medium. This model is histologically similar to the in vivo vaginal mucosa.

Alternatives to Animal Testing
SkinEthicTM HGE / Human Gingival Epithelium The SkinEthicTM HGE model is composed of normal human gingival cells cultivated on an inert polycarbonate filter at the air liquid interface in a chemically defined medium. This model is histologically similar to the outer cell layers of the human gum.
EPISKIN
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The SkinEthicTM HGE model is composed of normal human gingival cells cultivated on an inert polycarbonate filter at the air liquid interface in a chemically defined medium. This model is histologically similar to the outer cell layers of the human gum.

Alternatives to Animal Testing
SkinEthicTM HOE / Human Oral Epithelium The SkinEthicTM HOE model is composed of TR146 cells (derived from a squamous cell carcinoma of the buccal mucosa) cultivated on an inert polycarbonate filter at the air liquid interface in a chemically defined medium. This model forms an epithelial tissue devoid of stratum corneum, resembling histologically to the mucosa of the oral cavity.
EPISKIN
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The SkinEthicTM HOE model is composed of TR146 cells (derived from a squamous cell carcinoma of the buccal mucosa) cultivated on an inert polycarbonate filter at the air liquid interface in a chemically defined medium. This model forms an epithelial tissue devoid of stratum corneum, resembling histologically to the mucosa of the oral cavity.

Alternatives to Animal Testing
SkinEthicTM HCE / Human Corneal Epithelium The SkinEthicTM HCE model is composed of transformed human corneal keratinocytes cultivated on an inert polycarbonate filter at the air liquid interface in a chemically defined medium. The reconstructed tissue forms a stratified and well organized epithelium which is structurally, morphologically and functionnally similar to the human cornea with presence of basal, wing and mucus production cells.
EPISKIN
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The SkinEthicTM HCE model is composed of transformed human corneal keratinocytes cultivated on an inert polycarbonate filter at the air liquid interface in a chemically defined medium. The reconstructed tissue forms a stratified and well organized epithelium which is structurally, morphologically and functionnally similar to the human cornea with presence of basal, wing and mucus production cells.

Alternatives to Animal Testing