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SkinEthicTM HVE / Human Vaginal Epithelium The SkinEthicTM HVE model is composed of A431 cells (derived from a vulval epidermoid carcinoma) cultivated on an inert polycarbonate filter at the air liquid interface in a chemically defined medium. This model is histologically similar to the in vivo vaginal mucosa.
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The SkinEthicTM HVE model is composed of A431 cells (derived from a vulval epidermoid carcinoma) cultivated on an inert polycarbonate filter at the air liquid interface in a chemically defined medium. This model is histologically similar to the in vivo vaginal mucosa.

Alternatives to Animal Testing
SkinEthicTM HGE / Human Gingival Epithelium The SkinEthicTM HGE model is composed of normal human gingival cells cultivated on an inert polycarbonate filter at the air liquid interface in a chemically defined medium. This model is histologically similar to the outer cell layers of the human gum.
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The SkinEthicTM HGE model is composed of normal human gingival cells cultivated on an inert polycarbonate filter at the air liquid interface in a chemically defined medium. This model is histologically similar to the outer cell layers of the human gum.

Alternatives to Animal Testing
SkinEthicTM HOE / Human Oral Epithelium The SkinEthicTM HOE model is composed of TR146 cells (derived from a squamous cell carcinoma of the buccal mucosa) cultivated on an inert polycarbonate filter at the air liquid interface in a chemically defined medium. This model forms an epithelial tissue devoid of stratum corneum, resembling histologically to the mucosa of the oral cavity.
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The SkinEthicTM HOE model is composed of TR146 cells (derived from a squamous cell carcinoma of the buccal mucosa) cultivated on an inert polycarbonate filter at the air liquid interface in a chemically defined medium. This model forms an epithelial tissue devoid of stratum corneum, resembling histologically to the mucosa of the oral cavity.

Alternatives to Animal Testing
SkinEthicTM HCE / Human Corneal Epithelium The SkinEthicTM HCE model is composed of transformed human corneal keratinocytes cultivated on an inert polycarbonate filter at the air liquid interface in a chemically defined medium. The reconstructed tissue forms a stratified and well organized epithelium which is structurally, morphologically and functionnally similar to the human cornea with presence of basal, wing and mucus production cells.
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The SkinEthicTM HCE model is composed of transformed human corneal keratinocytes cultivated on an inert polycarbonate filter at the air liquid interface in a chemically defined medium. The reconstructed tissue forms a stratified and well organized epithelium which is structurally, morphologically and functionnally similar to the human cornea with presence of basal, wing and mucus production cells.

Alternatives to Animal Testing
SkinEthicTM RHPE / Reconstructed Human Pigmented Epidermis The SkinEthicTM RHPE model is composed of normal human keratinocytes cultivated in the presence of melanocytes of phototype II, IV or VI, localized in the basal layer. The different tanning degrees of these constructs correspond macroscopically to 3 different phototypes of human skin.
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The SkinEthicTM RHPE model is composed of normal human keratinocytes cultivated in the presence of melanocytes of phototype II, IV or VI, localized in the basal layer. The different tanning degrees of these constructs correspond macroscopically to 3 different phototypes of human skin.

Alternatives to Animal Testing
EpiSkinTM Small or Large / Reconstructed Human Epidermis EpiSkinTM is an in vitro reconstructed human epidermis from normal human keratinocytes cultured on a collagen matrix at the air-liquid interface. This model exists at different stages of maturity. This model is histologically similar to the in vivo human epidermis.
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EpiSkinTM is an in vitro reconstructed human epidermis from normal human keratinocytes cultured on a collagen matrix at the air-liquid interface. This model exists at different stages of maturity.
This model is histologically similar to the in vivo human epidermis.

Alternatives to Animal Testing
RHE-LC / Human Epidermal Model Langerhans cells The SkinEthic™ RHE-LC model is a standard epidermal model in which Langerhans cells progenitors have been integrated. During the tissue reconstruction, these immature cells have differentiated into antigen-presenting Langerhans cells expressing the specific marker CD207 (langerin). They are mostly located and evenly spread within the supra-basal epidermal layer. The SkinEthic™ RHE-LC model is therefore expected to be a useful tool for skin immune response studies.
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The SkinEthic™ RHE-LC model is a standard epidermal model in which Langerhans cells progenitors have been integrated. During the tissue reconstruction, these immature cells have differentiated into antigen-presenting Langerhans cells expressing the specific marker CD207 (langerin). They are mostly located and evenly spread within the supra-basal epidermal layer.
The SkinEthic™ RHE-LC model is therefore expected to be a useful tool for skin immune response studies.

Alternatives to Animal Testing
SkinEthicTM RHE / Reconstructed Human Epidermis SkinEthicTM RHE is an in vitro reconstructed human epidermis from normal human keratinocytes cultured on an inert polycarbonate filter at the air-liquid interface. It is histologically similar to the in vivo human epidermis.
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SkinEthicTM RHE is an in vitro reconstructed human epidermis from normal human keratinocytes cultured on an inert polycarbonate filter at the air-liquid interface. It is histologically similar to the in vivo human epidermis.

Alternatives to Animal Testing
T-SkinTM / Reconstructed Human Full Thickness Skin Model T-SkinTM is an in vitro reconstructed skin which consists of a dermal equivalent with human fibroblasts overlaid by a stratified, well differentiated epidermis derived from normal human keratinocytes cultured on an inert polycarbonate filter. This model exists at different stages of maturity.
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T-SkinTM is an in vitro reconstructed skin which consists of a dermal equivalent with human fibroblasts overlaid by a stratified, well differentiated epidermis derived from normal human keratinocytes cultured on an inert polycarbonate filter.

This model exists at different stages of maturity.

Alternatives to Animal Testing
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