Not tested on animals or is not used for testing on animals
Short Description TubulinTracker is a novel fluorescent reporter cell assay to investigate the microtubule polymerisation dynamics, progression of cells through mitosis and aneugenicity. The assay has been developed as followup for the ToxTracker (ACE) assay, to further assess the mode-of-action of genotoxic compounds that were classified as aneugen. However, TubulinTracker can also be used as stand-alone Tubulin polymerisation assay.
Target Application(s) / Sector(s) / Disease(s) AOP approach for tubulin poisons, Follow-up of ToxTracker (ACE) for compounds with an aneugenic mode-of-action, Follow-up of a positive in vitro micronucleus test
